Graduate
May 14, 2022
The genetics of sex hormones and their effects on mammographic density in women
In this work we leveraged genomic information from large-scale population-based studies to explore the relationships between three epidemiologic factors associated with breast cancer in women: 1) mammographic density, 2) sex hormone concentrations, and 3) body mass index (BMI). Mammographic density, which describes the proportion of dense (i.e., epithelial and stromal) tissue in the breast, is…
Fusobacterium Nucleatum Enrichment in Colorectal Cancer and its Relationship with Tumor Attributes
Background: Aspects of the human gut microbiome have recently been linked to the etiology of colorectal cancer (CRC). Specifically, the commensal microbe Fusobacterium nucleatum (F. nucleatum) has been implicated in the development and progression of CRC, and has been found to be enriched in colorectal tumor tissue. Reflecting the fact that CRC is a heterogenous…
May 12, 2022
Effect of Internal Standard Normalization of Microbiome Data on Outcomes of a Controlled Feeding Study and a Longitudinal Study in a Multiethnic Cohort
Standardization would benefit the interpretability of human microbiome data because unintended variability can be introduced at each level of data production and processing. One way to bring standardization to microbiome studies is with internal standards (IS). In three microbiome sequencing methods—16S rRNA gene sequencing, and metagenomic and metatranscriptomic sequencing—this standardization can involve the addition of…
Association of CPS Post-Response Daycare Services with Child Physical Abuse Recidivism
Introduction: Provision of services to families is a tool used by child welfare agencies after child maltreatment is reported, with an intention of preventing future child maltreatment reports. Little is known about the effectiveness of individual services in preventing child physical abuse recidivism.Methods: A retrospective cohort study was performed of data from 23 states contributing…
The association between smartphone-derived population-level mobility and COVID-19 in 2020: a census tract-level analysis of King County
Stay-at-home orders were an important tool in mitigating the COVID-19 pandemic. This ecological study used small area estimation models to estimate the associations between mobility and social vulnerability with COVID-19 case counts under different lockdown conditions for all 397 census tracts in King County, Washington in 2020. Data was used from Safegraph’s Social Distancing Metrics…
COVID-19 Vaccine Hesitancy in a US Public University Cohort
COVID-19 is a threat to university reopening. Universities are sites of dense human contact, congregate living, and heterogenous mixing patterns that may increase risk of viral transmission within and between social groups. Understanding attitudes toward vaccine uptake is critical to strategic reopening. At the University of Washington, we conducted a prospective observational study of SARS-CoV-2…
Characterization of patients seeking care at a Sexual Health Clinic who report engaging in exchange sex
Background: People who exchange sex (PWES) for money or drugs are at increased risk of HIV and other sexually transmitted infections (STIs) and may need tailored prevention and care services. Our objective was to characterize patients in the Public Health – Seattle & King County Sexual Health Clinic who reported engaging in exchange sex and…
May 10, 2022
Contraceptive Use Among Cisgender Women with Bacterial Sexually Transmitted Infections: A Cross-Sectional Study
Little is known about contraceptive use among women with bacterial sexually transmitted infections (STIs), despite their high risk for unplanned pregnancy. This analysis describes contraceptive use and interest in long-acting reversible contraception (LARC) among women with bacterial STIs. This cross-sectional study included 1,623 women ages 13 to 45 with bacterial STIs who completed a public…
Hepatitis C Prevalence, Correlates, and Social Networks among Cisgender Women who Participate in Sex Work in Seattle, WA
Background: Globally, injection drug use (IDU) is common among cisgender women who participate in sex work (CWSW), placing them at heightened risk of HCV acquisition and transmission. However, the epidemiology of HCV among CWSW in the United States is not well understood. In this study among CWSW in Seattle, we sought to estimate HCV prevalence,…
Hyperoxia After Pediatric Cardiac Arrest: Association with Survival and Neurological Outcomes
Objective: To evaluate the association between hyperoxia in the first 24 hours after in-hospital pediatriccardiac arrest and mortality and poor neurological outcome. Design: Retrospective cohort study. Setting: Tertiary care freestanding children’s hospital. Patients: Patients younger than 18 years of age with in-hospital cardiac arrest between December 2012 and December 2019, who achieved return of circulation…
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