Graduate
May 16, 2022
The Utilization and Safety of Per Oral Endoscopic Myotomy (POEM) for Achalasia in the US
Background: Clinical trials show that per oral endoscopic myotomy (POEM) has similar efficacy to pneumatic dilation (PD) and laparoscopic heller myotomy (LHM) for relief of achalasia symptoms. We describe the diffusion of POEM into clinical practice and evaluate unanswered questions regarding safety and the burden of healthcare utilization after POEM.Methods: Retrospective cohort study of achalasia…
Cervical cancer prevention in the context of abating HIV prevalence in Kenya
In 2020, the World Health Organization (WHO) launched an initiative to eliminate cervical cancer as a public health problem globally. While high-income countries are expected to achieve this goal in the coming decades, the timeline for elimination will be significantly longer for lower-resourced countries with high HIV burden. In low-and-middle income countries, HIV infection is…
Using Big Data to Improve Bacterial Sepsis Risk Stratification Among Immunocompromised Cancer Patients
Allogeneic hematopoietic stem cell transplant (HCT) recipients are an immunocompromised population that is disproportionately affected by sepsis, a life-threatening dysregulated immunologic response to an infection. While it is well established that early detection and treatment of sepsis with fluids and broad-spectrum antibiotics reduce the risk of mortality, recent data suggests early broad-spectrum antibiotic use in…
Effect of Human Immunodeficiency Virus Infection on Human Papillomavirus Clearance among Women in Senegal, West Africa
Background. Persistent infection with human papillomavirus (HPV) is associated with development of cervical-related disease.Methods. A total of 174 Senegalese women completed health questionnaires and were tested for Human Immunodeficiency Virus (HIV) upon enrollment, as well as were tested HPV at baseline and during follow up. The 2-year cumulative incidence of clearance of type-specific HPV infection…
Joint association between endogenous sex hormones, genetic risk factors, and incident venous thromboembolism in women
Venous thromboembolism (VTE) is associated with genetic variations and the use of exogenous hormones such as oral contraceptives and hormone therapy. Previous studies have shown an inconsistent association between endogenous hormone concentrations and markers of coagulation and fibrinolysis, known risk factors of VTE. Further, little is known about the joint effects of genetic and endogenous…
Assessing Climate Driven West Nile Virus Risk in Washington State
Background: West Nile virus (WNV) is becoming a significant public health concern in Washington State (WA). Climate factors likely impact WNV case numbers in WA, but this has not been widely explored. Methods: We examined the relationship between weekly averaged metrological conditions and reported WNV cases from 2006 to 2019 for two counties in Eastern…
Predictors of Velopharyngeal Insufficiency After Surgical Advancement of the Maxilla Among Young Adults with Cleft Palate
Introduction: Maxillary hypoplasia refers to undergrowth of the upper jaw and results in malocclusion of varying severity. While the prevalence of severe maxillary hypoplasia in the general population of the United States is 0.3%, the prevalence among patients with a cleft palate with or without cleft lip (CP/L) is more than 40%. The timeline of…
Analyzing trends in HSV Western Blot results at a Reference Laboratory
Objective: To better understand herpes simplex virus (HSV) Western Blot result trends over the past 20 years and to determine the proportion of Western Blot positivity for HSV-1 and HSV-2 and the proportion of results that are indeterminate. To examine the relationship between indeterminate results and age. Methods: We used de-identified HSV Western Blot data…
May 14, 2022
COVID-19 in Washington K-12 Schools: Time to first COVID-19 school outbreak characterized by learning modality and community transmission
BACKGROUND: There is limited research available on COVID-19 outbreaks in K-12 schools, and many schools will be looking for guidance on safely keeping schools open for the 2021-2022 school year. The primary purpose of this study was to examine the relationship between learning modality and time to assess whether there was a relationship between community…
Residential green space and behavioral and mental health outcomes in early childhood
BackgroundNatural environments, including urban green spaces, have been associated with a range of health outcomes across the life course. Green space may promote healthy development, even early in childhood. The aim of this study was to investigate the relationships between residential green space exposures and child behavioral and mental health in a socio-demographically diverse cohort…
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