Faculty

Nona Sotoodehnia

Adjunct Professor, Epidemiology
Professor, Medicine - Cardiology
Co-Director, Cardiovascular Health Research Unit, Medicine - Cardiology
John Laughlin Endowed Professorship in Cardiovascular Research, Medicine - Cardiology

206-287-2777

Education

MPH Harvard School of Public Health, 1996
MD Harvard Medical School, 1996
BS Massachusetts Institute of Technology, 1991

Contact

206-287-2777

Box 359748
WA

Bio

Dr. Sotoodehnia, the John and Cookie Laughlin Endowed Professor in Cardiology, is co-director of the Cardiovascular Health Research Unit. She is a general cardiologist at Harborview Medical Center.

She conducts research on the genomics and epidemiology of cardiovascular diseases and risk factors. Her research focus includes cardiac arrhythmias and sudden cardiac arrest, diabetes and coronary heart disease. She and her group are leading efforts in precision medicine, examining drug-gene interactions, risk prediction and drug safety. Her work investigates gender and ethnic differences in cardiovascular risk and outcomes. In addition, she has a long interest in international health and is helping lead efforts in cardiovascular treatments in Nepal.

Research Interests

  • Preventive cardiology
  • Arrhythmias including sudden cardiac death and atrial fibrillation
  • Coronary heart disease
  • Precision medicine
  • International health
  • Diabetes and gender 
  • Ethnic differences in cardiovascular risk and outcomes

Recent Publications (PubMed)

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
(2025 Jun 20)
Transl Psychiatry 15(1): 207
Bentley AR, Brown MR, Musani SK, Schwander KL, Winkler TW, Sims M, Kilpeläinen TO, Aschard H, Bartz TM, Bielak LF, Chai JF, Chitrala KN, Franceschini N, Graff M, Guo X, Hartwig FP, Horimoto ARVR, Lim E, Liu Y, Manning AK, Nolte IM, Noordam R, Richard MA, Smith AV, Sung YJ, Vojinovic D, Wang R, Wang Y, Feitosa MF, Harris SE, Lyytikäinen LP, Pistis G, Rauramaa R, van der Most PJ, Ware E, Weiss S, Wen W, Yanek LR, Arking DE, Arnett DK, Ballantyne C, Boerwinkle E, Chen YI, Daviglus ML, de Las Fuentes L, de Vries PS, Delaney JAC, Fretts AM, Ekunwe L, Faul JD, Gallo LC, Heikkinen S, Homuth G, Ikram MA, Isasi CR, Jonas JB, Keltikangas-Järvinen L, Komulainen P, Kraja AT, Krieger JE, Launer L, Lifelines Cohort Study, Liu J, Lohman K, Luik AI, Manichaikul AW, Marques-Vidal P, Milaneschi Y, Mwasongwe SE, O'Connell JR, Rice K, Rich SS, Schreiner PJ, Schwettmann L, Shikany JM, Shu XO, Smith JA, Snieder H, Sotoodehnia N, Tai ES, Taylor KD, Tinker L, Tsai MY, Uitterlinden AG, van Duijn CM, van Heemst D, Waldenberger M, Wallace RB, Wee HL, Weir DR, Wei WB, Willems van Dijk K, Wilson G, Yao J, Young KL, Zhang X, Zhao W, Zhu X, Zonderman AB, Deary IJ, Gieger C, Grabe HJ, Lakka TA, Lehtimäki T, Oldehinkel AJ, Preisig M, Wang YX, Zheng W, Evans MK, Province M, Gauderman J, Gudnason V, Hartman CA, Horta BL, Kardia SLR, Kooperberg C, Liu CT, Mook-Kanamori DO, Penninx BW, Pereira AC, Peyser PA, Psaty BM, Rotter JI, Sim X, North KE, Rao DC, Bierut L, Miller CL, Morrison AC, Rotimi CN, Fornage M, Fox ER

Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.
(2025 May 20)
Atherosclerosis 407(): 120219
Lundin JI, Peters U, Hu Y, Ammous F, Benjamin EJ, Bis JC, Brody JA, Cushman M, Fuller H, Gignoux C, Guo X, Haessler J, Haiman C, Joehanes R, Kasela S, Kenny E, Lappalainen T, Levy D, Liu C, Liu Y, Loos RJF, Matise T, North KE, Park SL, Ratliff SM, Reiner A, Rich SS, Rotter JI, Smith JA, Sotoodehnia N, Tracy R, Van den Berg D, Ye T, Zhao W, Raffield LM, Kooperberg C, PAGE Study

Ultra-processed foods, plant and animal sources, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study.
(2025 Jun 2)
Am J Clin Nutr
Feinberg A, Rebholz CM, Lemaitre RN, Fretts AM, Wiggins K, Sotoodehnia N, Psaty BM, Kim H

Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation.
(2025 May 20)
Nat Commun 16(1): 4678
Kirmani S, Huan T, Van Amburg JC, Joehanes R, Uddin MM, Nguyen NQH, Yu B, Brody JA, Fornage M, Bressler J, Sotoodehnia N, Ong DA, Puddu F, Floyd JS, Ballantyne CM, Psaty BM, Raffield LM, Natarajan P, Conneely KN, Weinstock JS, Carson AP, Lange LA, Ferrier K, Heard-Costa NL, Murabito J, Bick AG, Levy D

Comparison of long COVID, recovered COVID, and non-COVID Post-Acute Infection Syndromes over three years.
(2025)
PLoS One 20(5): e0323104
Carr CR, Gentile NL, Bertolli J, Szewczyk W, Lin JS, Unger ER, Vu QM, Sotoodehnia N, Fitzpatrick AL

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