Faculty

Adrienne E Shapiro

Adjunct Assistant Professor, Epidemiology
Assistant Professor, Global Health
Assistant Professor, Medicine - Allergy and Infectious Dis.

206-520-4268

Education

AB Harvard University, 2002
MSc London School of Hygiene & Tropical Medicine (UK), 2003
MD Johns Hopkins University, 2013
PhD Epidemiology, Johns Hopkins University, 2013

Contact

206-520-4268

Box 359927
325 9th Ave
Office 1232
Seattle, WA 98104
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Bio

Adrienne Shapiro, MD, PhD (she/her), is an Assistant Professor in the Departments of Global Health and Medicine (Infectious Diseases) at the University of Washington and is Associate Medical Director of the Seattle Vaccine Trials Unit at the Fred Hutch Cancer Center. Her research focuses on strategies to improve diagnosis and prevention of tuberculosis (TB), particularly for people with HIV and in low and middle income country settings. She is principal investigator a project to develop optimized TB diagnostic algorithms using novel point-of-care diagnostic tools for TB and leads studies of delivery approaches to improve access to TB preventive therapy to people at risk for TB. Dr. Shapiro conducts clinical trials of new medications to prevent HIV and vaccines to prevent HIV, TB, and other infections. Working with the CNICS consortium, a large multi-site cohort of people living with HIV in the United States, Dr. Shapiro studies vaccine uptake and the effect of emerging infections in this population, including COVID-19 and mpox. Her investigative methods include clinical trials, implementation science studies, and observational epidemiologic approaches with cohort studies and diagnostic test accuracy studies. In addition, she serves as an evidence reviewer for the WHO and other national advisory bodies to translate research evidence into clinical and public health practice guidelines. Clinically, Dr. Shapiro serves as a primary care physician for people living with HIV and attends on the inpatient Infectious Diseases consult service at Harborview Medical Center.

Recent Publications (PubMed)

ThiPhiSA: new pathways to TB prevention from community screening - a household-randomised controlled trial in KwaZulu-Natal, South Africa.
(2025 Aug 12)
BMJ Open 15(8): e100927
Misra S, Madonsela T, Thomas KK, Grabow C, Lenn M, Morton JF, Reither K, Lynen L, van Heerden A, Essack Z, Bosman S, Shapiro AE

Diagnostic accuracy of tongue swab testing in persons with sputum Xpert Ultra Trace results.
(2025 Jul 16)
medRxiv
Shapiro AE, Dalmat RR, Mukwatamundu J, Kamoga C, Ngwane MW, Steadman A, Budiawan E, Stein G, Nalutaaya A, Mukiibi J, Nantale M, Biché P, Visek C, Sung J, Magcaba Z, Ngcobo N, Morton JF, Lenn M, Aucock S, Draper R, Ganguloo A, Wilson D, Katamba A, Kendall EA, Drain PK

Cumulative TB disease burden following sputum Xpert Ultra 'Trace' results in clinical settings: Results from a multi-site observational clinical study.
(2025 Jul 15)
medRxiv
Dalmat RR, Visek C, Budiawan E, Stein G, Nalutaaya A, Mukiibi J, Nantale M, Biché P, Sung J, Magcaba Z, Ngcobo N, Morton JF, Lenn M, Aucock S, Shapiro AE, Steadman A, Draper R, Ganguloo A, Wilson D, Katamba A, Kendall EA, Drain PK

Xpert MTB/RIF Ultra assay for pulmonary tuberculosis and rifampicin resistance in adults and adolescents.
(2025 Jul 29)
Cochrane Database Syst Rev 7(7): CD009593
Horne DJ, Zifodya JS, Shapiro AE, Church EC, Kreniske JS, Kay AW, Scandrett K, Steingart KR, Takwoingi Y

Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.
(2025 Jan)
Am J Respir Crit Care Med 211(1): 15-33
Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, Acuña-Villaorduña C, Barry PM, Bastos ML, Carr W, Chami H, Chen LL, Chorba T, Daley CL, Garcia-Prats AJ, Holland K, Konstantinidis I, Lipman M, Battista Migliori G, Parvez FM, Shapiro AE, Sotgiu G, Starke JR, Starks AM, Thakore S, Wang SH, Wortham JM, Nahid P

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