Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study
Rare coding mutations underlying deficiences of antithrombin and proteins C and S contribute to familial venous thromboembolism (VTE). It is uncertain whether rare variants play a role in the etiology of VTE in the general population.
Tea consumption patterns in relation to diet quality among children and adults in the United States: analyses of NHANES 2011-2016 data
The present analyses, based on two 24-hour dietary recalls for 17,506 persons in the 2011-2016 National Health and Nutrition Examination Survey database, explores tea consumption patterns in relation to demographics, diet quality, cardiovascular disease biomarkers, and body weight.
Benchmarking global trauma care: defining the unmet need for trauma surgery in Ghana
The researchers sought to determine Ghana's annual trauma operation rate in juxtaposition to New Zealand, the Lancet Commision on Global Surgery's benchmark nation.
Bayesian hierarchical spatial models: implementing the Besag York Mollié model in stan
This report presents a new implementation of the Besag-York-Mollié model in Stan, a probabilistic programming platform which does full Bayesian inference using Hamiltonian Monte Carlo.
Effect of mailed human papillomavirus test kits vs usual care reminders on cervical cancer screening uptake, precancer detection, and treatment: a randomized clinical trial
The objective of this study was to evaluate effectiveness of mailed HPV self-sampling kits versus usual care reminders for in-clinic screening to increase detection and treatment of cervical intraepithelial neoplasia grade two or worse and uptake of cervical cancer screenings.
PrEP discontinuation and prevention-effective adherence: experiences of PrEP users in Ugandan HIV serodiscordant couples
Optimal adherence to oral pre-exposure prohpylaxis for HIV prevention involves aligning consistent PrEP use with periods of risk to achieve prevention-effective adherence. For stable, serodiscordant couples, antiretroviral therapy adherence by the HIV-positive partner markedly decreases HIV transmission risk, potentially obviating the need for continued PrEP use; yet little is known about actual lived experiences of discontinuing PrEP.
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
Venous thromboembolism is a significant cause of mortality, yet it genetic determinants are incompletely defined. The researchers performed a discovery genome-wide association study in the Million Veteran Program and UK Biobank, with testing of approximately 13 million DNA sequence variants for association with venous thromboembolism and meta-analyzed both studies.
Time trends in first episode genital herpes simplex virus infections in an urban STD clinic
Genital herpes simplex virus type-1 has emerged as the leading cause of first episode genital herpes among specific populations in the U.S., such as adolescents, young adult women, and men who have sex with men. The researchers examined trends in the etiology of first episode genital herpes diagnoses over time in an STD clinic population.
Effect of cryotherapy vs loop electrosurgical excision procedure on cervical disease recurrence among women with HIV and high-grade cervical lesions in Kenya: a randomized clinical trial
The World Health Organization recommends cryotherapy or loop electrosurgical excision procedure for histologically confirmed cervical intraepithelial neoplasia grade 2 or higher regardless of HIV status. Cryotherapy is more feasible in resource-limited settings but may be less effective for women living with HIV.
Disseminating evidence-based interventions in small, low-wage worksites: a randomized controlled trial in King County, Washington (2014-2017)
The objectives of this study were to determine whether participating in HealthLinks and adding wellness committees to HealthLinks increases worksites' evidence-based intervention implementation.