Modifiable predictors of ventricular ectopy in the community
Premature ventricular contractions (PVCs) predict heart failure and death. Data regarding modifiable risk factors for PVCs are scarce.
Metabolites associated with the risk of incident venous thromboembolism: a metabolomic analysis
Venous thromboembolism ( VTE ) is a complex thrombotic disorder that constitutes a major source of mortality and morbidity. To improve understanding of the cause of VTE, the researchers conducted a metabolomic analysis in a case-control study including 240 incident VTE cases and 6963 controls nested within 3 large prospective population-based cohorts, the Nurses' Health Study, the Nurses' Health Study II, and the Health Professionals Follow-Up Study.
Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin
The researchers tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obese women 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial.
Is schizophrenia a risk factor for breast cancer?-evidence from genetic data
Observational epidemiological studies have found an association between schizophrenia and breast cancer, but it is not known if the relationship is a causal one. The researchers used summary statistics from very large genome-wide association studies of schizophrenia (n = 40675 cases and 64643 controls) and breast cancer (n = 122977 cases and 105974 controls) to investigate whether there is evidence that the association is partly due to shared genetic risk factors and whether there is evidence of a causal relationship. Using LD-score regression, the researchers found that there is a small but significant genetic correlation (rG) between the 2 disorders (rG = 0.14, SE = 0.03, P = 4.75 × 10-8), indicating shared genetic risk factors.
Feasibility of high-flow nasal cannula implementation for children with acute lower respiratory tract disease in rural Kenya.
High-flow nasal cannula (HFNC) is a well-established respiratory support device in high-income countries, but to our knowledge, its use in sub-Saharan Africa has not been reported. This feasability study describes the implementation process of HFNC in rural Kenya.
Firearm storage and Adult alcohol misuse among Washington state households with children
Firearm injuries and fatalities among children are an important public health problem. Children living with an adult misusing alcohol may be at a heightened risk for self-harm or unintentional injury, highlighting the need to investigate the association between household firearm storage and adult alcohol misuse.
Evaluating academic mentorship programs in low- and middle-income country institutions: proposed framework and metrics
Implementing innovations in public health agency preparedness and response programs
Failures in maintaining accurate and robust communication and information flows are often responsible for impeding organizations’ abilities to make informed decisions and work together during emergencies. Numerous tools and trainings have been developed to improve public health preparedness and response (PHPR) communications, but effectively implementation of evidence-based PHPR system improvements is unclear, and systematic uptake and adoption of evidence-based innovations into public health agencies has been limited.
Expanding methodologies to identify high-priority emergency preparedness tools for implementation in public health agencies
From analysis of recent emergencies, a consistent finding is that communication is among the most important factors in emergency response effectiveness. Communications failures, contradictions, and delays among response partners, key authorities, and the community can contribute to avoidable morbidity and mortality
Child protection reports and removals of infants diagnosed with prenatal substance exposure.
A frequent response for prenatal substance exposure (PSE) is intervention by child protective services (CPS). Previous research has examined differences in reports to CPS regarding PSE by substance exposure and by maternal race. However, little is known regarding the frequency of immediate removals by CPS relating to PSE and maternal race.