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Tenofovir and tenofovir-diphosphate concentrations during pregnancy among HIV-uninfected women using oral pre-exposure prophylaxis

AIDS, Thursday, June 14, 2018

Pregnancy is a time of increased HIV acquisition risk and pregnancy reduces concentrations of antiretrovirals used for treatment. Researchers assessed whether pregnancy lowers concentrations of tenofovir (TFV) and tenofovir-diphosphate (TFV-DP) among HIV-uninfected women using oral pre-exposure prophylaxis (PrEP).

Why neighborhood park proximity is not associated with total physical activity

Health & Place, Thursday, June 14, 2018

This study explored how parks within the home neighborhood contribute to total physical activity (PA) by isolating park-related PA.

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Nature Communications, Monday, June 11, 2018

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here researchers apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis.

Multi-ethnic genome-wide association study for atrial fibrillation

Nature Genetics, Monday, June 11, 2018

Atrial fibrillation affects more than 33 million individuals worldwide and has a complex heritability. Researchers conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. 

Model-estimated effectiveness of single dose 9-valent HPV vaccination for HIV-positive and HIV-negative females in South Africa

Vaccine, Friday, June 8, 2018

Women in sub-Saharan Africa have high dual burden of HPV and HIV infections, which can interact to increase cervical cancer (CC) risk. The 9-valent HPV (9vHPV) vaccine has high demonstrated effectiveness against HPV types causing 90% of CC. Additionally, one dose of the 9vHPV vaccine has the potential to achieve greater coverage at lower costs than a two-dose schedule. However, the potential impact of single-dose 9vHPV vaccine accounting for HPV-HIV interactions has not been estimated.

AA9int: SNP interaction pattern search using non-hierarchical additive model set

Bioinformatics, Thursday, June 7, 2018

The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature.

Longitudinal examination of the influence of individual posttraumatic stress disorder symptoms and clusters of symptoms on the initiation of cigarette smoking

Journal of Addiction Medicine, Wednesday, June 6, 2018

The aim of this study was to determine whether specific individual posttraumatic stress disorder (PTSD) symptoms or symptom clusters predict cigarette smoking initiation.

Ethnic, geographic, and genetic differences in arsenic metabolism at low arsenic exposure: A preliminary analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)

International Journal of Environmental Research and Public Health, Tuesday, June 5, 2018

Researchers investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA).

Posttraumatic Stress Disorder symptom association with subsequent risky and problem drinking initiation

Journal of Addiction Medicine, Monday, June 4, 2018

Posttraumatic stress disorder (PTSD) and unhealthy alcohol use are commonly associated conditions. It is unknown whether specific symptoms of PTSD are associated with subsequent initiation of unhealthy alcohol use.

Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry

The Pharmacogenomics Journal, Friday, June 1, 2018

Researchers evaluated interactions of SNP-by-ACE-I/ARB and SNP-by-TD on serum potassium (K+) among users of antihypertensive treatments (anti-HTN).