Roland Walter
Adjunct Professor, Epidemiology
Professor, Medicine - Hematology
Adjunct Professor, Laboratory Medicine and Pathology
206-667-3599
rwalter@fredhutch.org
Education
MD Medicine, University of Zurich (Switzerland), 1997
PhD Experimental Pathology, University of Washington, 2006
MS Epidemiology (Clinical Research), University of Washington, 2011
Contact
206-667-3599
rwalter@fredhutch.org
100 Fairview Ave. N., D2-190
Seattle, WA 98109
Bio
My research is focused on acute myeloid leukemia (AML). I am particularly interested in improving antibody-based therapies, both by optimizing the efficacy/safety profile of existing therapeutics and through the preclinical and early clinical development of novel antigen-directed immunotherapies. As examples of latter efforts, my lab has contributed to candidate drug identification and preclinical development of 5 novel agents that have subsequently advanced to clinical testing (SGN-CD33A, SGN-CD123A, AMG 330, AMV-564, and APVO436). A major area of focus of our research lies in the delineation of the mechanisms of action and resistance that are relevant for antibody-based AML therapeutics and the rational development of combination therapies that can overcome drug resistance. Many of my studies conducted over the last 15+ years have aimed at optimizing CD33-targeted and, more recently, CD123-targeted therapies. In clinical studies, I conduct trials testing novel treatments and innovative care approaches for AML patients. Furthermore, in collaborative research, I use large patient datasets to develop and improve diagnostic and prognostic tools for people with AML.
Research Areas
Research Interests
- Acute myeloid leukemia
- CD33
- Immunotherapy of AML
- Clinical trials in AM
- Measurable residual disease (MRD)
- Predictive modeling
Recent Publications (PubMed)
(2023 Mar 20)
Leuk Lymphoma
Cassaday RD, Zarling LC, Garcia KA, Sala-Torra O, Stevenson PA, Martino CH, Liu YJ, Fang M, Percival MM, Halpern AB, Becker PS, Oehler VG, Shustov AR, Cooper JP, Orozco JJ, Hendrie PC, Walter RB, Radich JP, Soma LA, Estey EH
(2023 Mar 9)
Leuk Lymphoma
Kopmar NE, Gooley T, Curley N, Russell K, Shaw C, Schonhoff K, Lim J, Halpern AB, Walter RB, Scott BL, Appelbaum J, Hendrie PC, Estey EH, Percival MM
(2023 Mar 8)
Leuk Lymphoma
Zhang MY, Othus M, Shaw C, Schonhoff KG, Halpern AB, Appelbaum J, Hendrie PC, Walter RB, Estey EH, Percival MM
(2023 Feb 23)
bioRxiv
Borot F, Humbert O, Newby GA, Fields E, Kohli S, Radtke S, Laszlo GS, Mayuranathan T, Ali AM, Weiss MJ, Yen JS, Walter RB, Liu DR, Mukherjee S, Kiem HP
(2023 Feb 15)
Blood Adv
Lindsay J, Walti CS, Halpern AB, Xie H, Chung EL, Schonhoff KG, Huebner EM, Cheng GS, Kimball L, Leisenring WM, Greenwood M, Chen SC, Kong DC, Slavin MA, Boeckh M, Fredricks D, Liu C, Pergam SA, Walter RB, Hill JA
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