Faculty

Roland Walter

Adjunct Professor, Epidemiology
Associate Professor, Medicine - Hematology
Professor, Medicine - Hematology
Adjunct Professor, Laboratory Medicine and Pathology

206-667-3599
rwalter@fredhutch.org

Education

MD Medicine, University of Zurich (Switzerland), 1997
PhD Experimental Pathology, University of Washington, 2006
MS Epidemiology (Clinical Research), University of Washington, 2011

Contact

206-667-3599
rwalter@fredhutch.org

Fred Hutchinson Cancer Research Center
100 Fairview Ave. N., D2-190
Seattle, WA 98109
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Bio

My translational and clinical research program is focused on human acute leukemia, in particular acute myeloid leukemia (AML) but, more recently, also acute lymphoblastic leukemia (ALL). I am particularly interested in the preclinical and early clinical development of novel antigen-directed immunotherapies for acute leukemia and the delineation of the mechanisms of action and resistance that are relevant for these agents. Many of these studies are aimed at optimizing the use of CD33-targeted immunotherapy. We are also investigating the molecular and phenotypic characteristics of leukemia stem and progenitor cells to understand how antigen-directed immunotherapies can be best utilized to eliminate these cells. In clinical studies, I conduct trials testing novel treatments and innovative care approaches for acute leukemia patients. Furthermore, in collaborative research, I use large patient datasets to develop and improve diagnostic and prognostic tools in acute leukemia.  

Research Areas

Research Interests

  • Acute myeloid leukemia
  • CD33
  • Immunotherapy of AML
  • Clinical trials in AM
  • Measurable residual disease (MRD)
  • Predictive modeling

Recent Publications (PubMed)

Conditioning Intensity and Peri-Transplant Flow Cytometric MRD Dynamics in Adult AML.
(2022 Jan 7)
Blood
Paras G, Morsink LM, Othus M, Milano F, Sandmaier BM, Zarling LC, Palmieri R, Schoch G, Davis C, Bleakley M, Flowers ME, Deeg HJ, Appelbaum FR, Storb RF, Walter RB

Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party.
(2022 Jan)
Hemasphere 6(1): e676
Tettero JM, Freeman S, Buecklein V, Venditti A, Maurillo L, Kern W, Walter RB, Wood BL, Roumier C, Philippé J, Denys B, Jorgensen JL, Bene MC, Lacombe F, Plesa A, Guzman ML, Wierzbowska A, Czyz A, Ngai LL, Schwarzer A, Bachas C, Cloos J, Subklewe M, Fuering-Buske M, Buccisano F

Cerebrospinal fluid flow cytometry and risk of central nervous system relapse after hyperCVAD in adults with acute lymphoblastic leukemia.
(2021 Dec 21)
Cancer
Garcia KA, Cherian S, Stevenson PA, Martino CH, Shustov AR, Becker PS, Percival MM, Oehler VG, Halpern AB, Walter RB, Orozco JJ, Keel SB, Estey EH, Cassaday RD

Elihu H. Estey, MD: Leukaemia expert, statistician, and gentle soul (July 15, 1946-October 8, 2021).
(2022 Jan)
Bone Marrow Transplant 57(1): 140-142
Walter RB, Gale RP

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party.
(2021 Dec 30)
Blood 138(26): 2753-2767
Heuser M, Freeman SD, Ossenkoppele GJ, Buccisano F, Hourigan CS, Ngai LL, Tettero JM, Bachas C, Baer C, Béné MC, Bücklein V, Czyz A, Denys B, Dillon R, Feuring-Buske M, Guzman ML, Haferlach T, Han L, Herzig JK, Jorgensen JL, Kern W, Konopleva MY, Lacombe F, Libura M, Majchrzak A, Maurillo L, Ofran Y, Philippe J, Plesa A, Preudhomme C, Ravandi F, Roumier C, Subklewe M, Thol F, van de Loosdrecht AA, van der Reijden BA, Venditti A, Wierzbowska A, Valk PJM, Wood BL, Walter RB, Thiede C, Döhner K, Roboz GJ, Cloos J

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