School of Public Health

Walter, Roland

Roland B. Walter

Associate Professor, Medicine - Hematology
Adjunct Associate Professor, Epidemiology
Adjunct Associate Professor, Pathology

Associate Member, Clinical Research Division, Fred Hutchinson Cancer Research Center

Education

MD Medicine, University of Zurich (Switzerland), 1997
PhD Experimental Pathology, University of Washington, 2006
MS Epidemiology (Clinical Research), University of Washington, 2011

Contact Info

Fred Hutchinson Cancer Research Center
100 Fairview Ave. N., D2-190
Seattle, WA 98109
Tel: 206-667-3599
rwalter@fredhutch.org
http://depts.washington.edu/hemeweb/research/walter.htm

My translational and clinical research program is focused on human acute leukemia, in particular acute myeloid leukemia (AML) but, more recently, also acute lymphoblastic leukemia (ALL). I am particularly interested in the preclinical and early clinical development of novel antigen-directed immunotherapies for acute leukemia and the delineation of the mechanisms of action and resistance that are relevant for these agents. Many of these studies are aimed at optimizing the use of CD33-targeted immunotherapy. We are also investigating the molecular and phenotypic characteristics of leukemia stem and progenitor cells to understand how antigen-directed immunotherapies can be best utilized to eliminate these cells. In clinical studies, I conduct trials testing novel treatments and innovative care approaches for acute leukemia patients. Furthermore, in collaborative research, I use large patient datasets to develop and improve diagnostic and prognostic tools in acute leukemia.  

Research Interests

  • Acute myeloid leukemia
  • CD33
  • Immunotherapy of AML
  • Clinical trials in AM
  • Measurable residual disease (MRD)
  • Predictive modeling

Research Areas 

Publications