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Prevalence, magnitude, and correlates of HIV-1 genital shedding in women on antiretroviral therapy

The Journal of Infectious Diseases, Tuesday, December 19, 2017

Genital human immunodeficiency virus (HIV) RNA shedding can continue despite HIV being undetectable in blood, and can be associated with transmission.

What are the risk factors associated with hospital birth among women planning to give birth in a birth center in Washington State?

Birth: Issues in Perinatal Care, Monday, December 18, 2017

This study describes the obstetrical risk factors for hospital birth among women intending to deliver in a birth center in Washington State.

Women's beliefs about what causes obesity: variation by race/ethnicity and acculturation in a Washington State sample

Ethnicity & Health, Friday, December 15, 2017

Individuals' beliefs about the causes of multifactorial health conditions (causal attributions) shape how they conceptualize and respond to health threats and are therefore important for health promotion. Studies of racial/ethnic and cultural variation in obesity causal beliefs, however, are scarce.

Modeling HIV disease progression and transmission at population-level: The potential impact of modifying disease progression in HIV treatment programs

Epidemics, Tuesday, December 5, 2017

Mathematical models that incorporate HIV disease progression dynamics can estimate the potential impact of strategies that delay HIV disease progression and reduce infectiousness for persons not on antiretroviral therapy.

Body mass index and breast cancer survival: a Mendelian randomization analysis

International Journal of Epidemiology, Friday, December 1, 2017

There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.

Mortality associated with metformin versus sulfonylurea initiation: A cohort study of veterans with diabetes and chronic kidney disease.

Journal of General Internal Medicine, Monday, November 27, 2017

For patients with type 2 diabetes and chronic kidney disease (CKD), high-quality evidence about the relative benefits and harms of oral glucose-lowering drugs is limited.

Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa

Gates Open Research, Monday, November 6, 2017

This study evaluates delivery of PrEP for HIV-negative partners within heterosexual HIV serodiscordant couples in an open-label demonstration project in East Africa. 

Maternal gestational weight gain and DNA methylation in young women: application of life course mediation methods

Epigenomics, Monday, November 6, 2017

The aim of this study was to investigate the role of maternal gestational weight gain (GWG) and prepregnancy BMI on programming offspring DNA methylation.

Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults

Neurobiology of Aging, Saturday, November 4, 2017

Thyroid hormone disease is common among older adults and is associated with cognitive impairment. However, pathologic correlates are not well understood. We studied pathologic and clinical factors associated with hypothyroidism, the most common manifestation of thyroid disease, in research subjects seen annually for clinical evaluations at U.S. Alzheimer's Disease Centers. 

Rationale and design of the HOME trial: A pragmatic randomized controlled trial of home-based human papillomavirus (HPV) self-sampling for increasing cervical cancer screening uptake and effectiveness in a U.S. healthcare system

Contemporary Clinical Trials, Saturday, November 4, 2017

Women who delay or do not attend Papanicolaou (Pap) screening are at increased risk for cervical cancer. Trials in countries with organized screening programs have demonstrated that mailing high-risk (hr) human papillomavirus (HPV) self-sampling kits to under-screened women increases participation, but U.S. data are lacking.  The trial was designed to evaluate whether a programmatic strategy incorporating hrHPV self-sampling is effective in promoting adherence to the complete screening process (including follow-up of abnormal screening results and treatment). The objective of this report is to describe the rationale and design of this pragmatic trial.