Incidence and predictors of clinical peripheral artery disease in asymptomatic persons with a low ankle–brachial index
This study sought to determine the occurrence of clinical peripheral artery disease in a cohort of middle-aged and older persons who, though they initially had no symptoms of peripheral artery disease, had blood pressure levels in the arteries of their ankles and feet that were at least 10% lower than those in the arteries of their arms.
Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study
Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length and colorectal cancer and its precursors, colorectal polyps, is not clear.
Protocol: a multi-level intervention program to reduce stress in 9-1-1 telecommunicators
Nationwide, emergency response systems depend on 9-1-1 telecommunicators to prioritize, triage, and dispatch assistance to those in distress. 9-1-1 call center telecommunicators (TCs) are challenged by acute and chronic workplace stressors: tense interactions with citizen callers in crisis; overtime; shift-work; ever-changing technologies; and negative work culture, including co-worker conflict. This workforce is also subject to routine exposures to secondary traumatization while handling calls involving emergency situations and while making time urgent, high stake decisions over the phone. Our study aims to test the effectiveness of a multi-part intervention to reduce stress in 9-1-1 TCs through an online mindfulness training and a toolkit containing workplace stressor reduction resources.
Chronic school absenteeism of children with chronic kidney disease
School attendance is associated with academic success. Early detection of children at high risk of frequent school absenteeism may allow for interventions to increase the likelihood of school completion. Children with chronic illness have an increased risk of absenteeism and lower academic achievement compared with children in general. School attendance in chronically ill children is associated with disease severity, disease control, physical limitations, psychological factors, and parental perception of their child's health.
Duration of spontaneous active labor and perinatal outcomes using contemporary labor curves
This study evaluated the association between spontaneous active labor duration utilizing contemporary labor curves and risk of adverse outcomes.
HIV self-testing increases HIV testing frequency in high risk men who have sex with men: A randomized controlled trial
Self-testing may increase HIV testing and decrease the time people with HIV are unaware of their status, but there is concern that absence of counseling may result in increased HIV risk.
Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study
Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. This study investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY.
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted loss-of-function (pLOF) variants provide insight into effector transcript and direction of biological effect.
Serum androgens and risk of atrial fibrillation in older men: The cardiovascular health study
Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined.
A trial of a single tablet regimen of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate for the initial treatment of HIV-2 infection in a resource-limited setting: 48 week results from Senegal, West Africa
There is an urgent need for safe and effective ART for HIV-2 infection. We undertook the first clinical trial of a single-tablet-regimen containing elvitegravir-cobicistat-emtricitabine-tenofovir disoproxil fumarate (E/C/F/TDF) to assess its effectiveness in HIV-2-infected individuals in Senegal, West Africa.