Perceived access and barriers to care among illicit drug users and hazardous drinkers: findings from the Seek, Test, Treat, and Retain data harmonization initiative (STTR)
Illicit drug use and hazardous drinking among marginalized populations may be associated with greater barriers to care.
Spatio-temporal coherence of dengue, chikungunya and Zika outbreaks in Merida, Mexico
Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from the city of Merida, Mexico, with the goal of assessing the utility of historical DENV data to infer CHIKV and ZIKV introduction and propagation.
Prognostic significance of large airway dimensions on computed tomography in the general population: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in COPD, and symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined. The goal of this study was to examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease.
Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation
The researchers conducted a joint metabolomic–epigenomic study to identify patterns of epigenetic associations with smoking-related metabolites.
Increased risk of female HIV-1 acquisition throughout pregnancy and postpartum: A prospective per-coital act analysis among women with HIV-1 infected partners
This study found the HIV-1 acquisition probability per condomless sex act steadily increased through pregnancy and was highest during the postpartum period, suggesting that biological changes during pregnancy and postpartum increase female HIV-1 susceptibility.
Individual and Neighborhood Stressors, Air Pollution and Cardiovascular Disease
The objective of this study is to evaluate the interaction between psychosocial stressors, at both the individual and neighborhood level, and air pollution on cardiovascular disease.
Risk of sudden sensorineural hearing loss in adults using phosphodiesterase type 5 inhibitors: Population-based cohort study
The objective of the study was to determine the risk of sudden sensorineural hearing loss associated with use of phosphodiesterase type 5 (PDE5) inhibitors.
Association of pre-pregnancy BMI and postpartum weight retention before second pregnancy, Washington State, 2003-2013
Maternal overweight and obesity is one of the most common high-risk obstetric conditions associated with adverse birth outcomes. Smaller studies have suggested that pre-pregnancy body mass index (BMI) is associated with postpartum weight retention. The primary objective of this study was to examine the association between pre-pregnancy BMI status and maternal weight retention.
Contribution of the in-vehicle microenvironment to individual ambient-source nitrogen dioxide exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution
Exposure estimates that do not account for time in-transit may underestimate exposure to traffic-related air pollution, but exact contributions have not been studied directly. To study this, the researchers conducted a two-week monitoring, including novel in-vehicle sampling, in a subset of the Multi-Ethnic Study of Atherosclerosis and Air Pollution cohort in two cities.
Genetic mechanisms of immune evasion in colorectal cancer
To understand the genetic drivers of immune recognition and evasion in colorectal cancer (CRC), the researchers analyzed 1,211 CRC primary tumor samples, including 179 classified as microsatellite instability-high.